Research

Compositional and Combinatorial Engineered Nanomaterial Libraries for Property-Activity Analysis - Theme 1 (ENM)

Leader: Jeffrey Zink

The primary goal of Theme 1 is to develop property-activity relationships between fundamental physical/chemical properties of nanoparticles and biological responses, and from these relationships to develop predictive models.  In a highly interactive feedback process, nanoparticles with designed physical and chemical properties are synthesized, characterized, and studied in Theme 2 using high content or high throughput methods to measure the responses of cells and organisms.  Evaluation of the responses leads to further synthesis of designed materials and further testing until the predictions of a model are validated (or rejected).  The successful models are shared with investigators in Themes 3-5 for incorporation in studies of transport and fate in the environment (Theme 3) and of terrestrial and aqueous ecosystems (Themes 4-5).

1. Toxicity of Engineered NanoMaterial with Cationic Surfaces

2. Processing and Characterization of Single Walled and Multi-Walled Carbon Nanotubes

3. Systematic Synthesis and Characterization of Silicon Dioxide Nanoparticles for Establishing Processing-Structure-Toxicity Relationships

4. FSP Generated Pure and Fe Doped ZnO or TiO2 NP Libraries for Testing Paradigms of Environmental and Cellular Responses

5. Relationships Between ENM Geometry and Biological Outcomes: Nanorods

6. Relationships Between ENM Geometry and Biological Outcomes: Nanowires

Core Activity B - Engineered NanoMaterial Acquisition, Characterization, Distribution